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10.14341/probl12724 29

Antipsychotic-induced insulin resistance and postprandial hormonal dysregulation independent of weight gain or psychiatric disease

doi: 10.1016/j.burns.2008.11.017 54 BermanBDuncanMR

10.1016/j.regpep.2007.01.003 29 ChoungH

Additionally, an obstacle to drug treatment for obesity is that the drug is perceived as ineffective because the patient gains weight again when the drug is stopped

Oral drugs undergo what is known as first-pass metabolism. First-pass metabolism is when the concentration of a drug, specifically when administered orally, is significantly reduced before it reaches systemic circulation