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Tier 2 (clinician contact within 48 hours): Vomiting more than twice daily for two consecutive days, constipation lasting more than five days without relief, or weight loss stalling with severe GI symptoms at a low dose

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The risks include skin tautness, redness, swelling, skin sensitivity, and slight bruising

Cost and access in the UK Both medications are available on the NHS for type 2 diabetes, subject to local prescribing guidelines