Ex-4 also activates GLP-1R-expressing neurons in the dorsomedial nucleus of the hypothalamus (DMH) and the dorsolateral septum (dLS) [4,5]
[DOI] [PubMed] [Google Scholar] Moore M.C., Werner U., Smith M.S., Farmer T.D., Cherrington A.D
GLP-1RAs play a key role in regulating the response to inflammation of the endothelium
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In fact, women with Lipedema often have: Normal blood sugar Higher adiponectin (a protective anti-inflammatory hormone) Unique inflammatory patterns in fat tissue Higher oxidative stress despite a healthy lifestyle Because of this, GLP-1s may help by: Supporting metabolic signalling Lowering inflammation Calming the immune system within fat tissue Reducing oxidative stress Improving energy levels Supporting long-term symptom relief You do not need to have obesity to see benefits
Dramatically increased efficacy, uptake, and adherence could lead to positive upside impacts relative to our central scenario best-estimate assumptions