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Obesity and Metabolic Syndrome Research in diet-induced obesity models showed that MOTS-c treatment resulted in: Significant reduction in body weight gain despite continued high-fat diet consumption Decreased adipose tissue accumulation and reduced hepatic steatosis Improved lipid profiles with reduced circulating triglycerides Enhanced metabolic flexibility between carbohydrate and fat oxidation Plasma metabolomics studies in obese mice identified MOTS-c-mediated decreases in metabolic markers associated with obesity and type 2 diabetes