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The exact way that topiramate causes weight loss is not fully understood

While a substitution with the polar serine at position 13 retained wild-type dehydratase activity, presumably due to the alcohols ability to assume cysteines function in stabilizing deprotonated GS , the only other Pt GSTF8 variants to keep analbeit reducedflavan-3,3,4-triol ( 4 ) dehydration activity contained a glycine, alanine or asparagine mutation (Fig

N = 6-10/cohort

A medications half-life is the amount of time it takes for the concentration of the drug in your bloodstream to be reduced by exactly one half