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[DOI] [PubMed] [Google Scholar] 289.Corley B.T., Carroll R.W., Hall R.M., Weatherall M., Parry-Strong A., Krebs J.D

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Secondly, they suppress the secretion of glucagon, a hormone produced by the alpha cells of the pancreas that raises blood sugar levels

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Figure 3 Table 1 summarizes major clinical trials evaluating the efficacy of GLP-1RAs across different organ systems, illustrating the expanding scope of their clinical utility

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It is evident that CNS GLP-1R signaling is essential for mediating the pharmacological action of GLP-1R agonists on energy metabolism as genetic deletion of CNS GLP-1R signaling in mice ablates the action of peripherally administered liraglutide on food intake and body weight reduction (Sisley et al., 2014)

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