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Another study supported that the stress of hyperglycemia induced the accumulation of advanced glycation end (AGE) products, which led to an increase in reactive oxygen species, the activation of inflammatory pathways and reduction of cardiac energy efficiency [42]

Current evidence from large-scale clinical trials does not establish a causal relationship, though post-marketing reports continue to be monitored

Addressing these areas will not only deepen the understanding of ferroptosisRF crosstalk but also facilitate the development of precise, translatable therapeutic strategies for CKD-related RF, an unmet clinical need

In parallel, intracellular lipid levels decreased in a dose-dependent manner, indicating a reduced pool available for sebum synthesis

doi: 10.1530/EDM-16-0123 18 CatargiBRigalleauVPoussinARonci-ChaixNBexVVergnotVet al

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