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These predispositions in GLP-1 sensitivity and metabolic response can inform discussions with your provider about whether a standard titration protocol or personalized dosing strategy is most appropriate for your physiology

A large retrospective cohort study from Weill Cornell Medical College - examining 255 patients (92% women, mean age 64) with DXA scans before and after starting semaglutide or tirzepatide - found that GLP-1 receptor agonist use was associated with greater annualized total hip bone loss in patients without diabetes, while patients with diabetes showed bone loss more comparable to non-users

This type of therapy is a common way to correct imbalances of electrolytes, something that can occur very easily in the heat

Start with lower dosages and gradually increase as tolerated

Fetal and umbilical Doppler ultrasound in high-risk pregnancies

It delays puberty by decreasing levels of LH and prolactin, inhibiting GnRH-induced LH release, and lowering testosterone productioneffects that can be reversed by the melatonin receptor MT1 blocker, luzindole (Frungieri et al., 2017)