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Last reviewed: June 2, 2026 Last updated: June 2, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Within the last 3 months, have you taken opiate pain medications and/or opiate-based street drugs

Searches of PubMed and ClinicalTrials.gov did not identify a peer-reviewed study or registered clinical trial of the exact four-component KLOW formulation reviewed for this article

1986, 137B: 231-237

as they all have side effects

[10] Patients on a microdose of 0.05 mg once daily lost about 6 lbs over 26 weeks