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Relatively common side effects Internal bleeding or itching at the injection site, diarrhea, constipation, headache Severe side effects hypoglycemia, pancreatitis, bowel obstruction, palpitations *Although GLP-1 alone rarely causes hypoglycemia, it has been reported that combined use with insulin or oral hypoglycemic agents can cause severe hypoglycemia

Clinical studies of GLP-1 medications have shown average weight reductions of around 10 20% of body weight when combined with healthy lifestyle changes

This ensures the medication is safe and effective while minimizing risks

In contrast, Tirzepatide specifically targets GLP-1 and GIP receptors

With respect to effects on food intake exerted via the hypothalamus when either OXM or GLP-1 are administered peripherally they exert differential neuronal activation within the hypothalamus

In Phase 2 trials, the mean heart rate increase was approximately 56 beats per minutean effect most healthy individuals don't consciously notice