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Since cuprizone regimen was several times higher than those regularly used in cuprizone studies (62) we used simple tests ( Tables 1-3 ) to determine animal responsiveness and impairment

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The analysis was carried out using a Thermo Scientific Vanquish LC coupled to Thermo Q Exactive HF MS

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In the case of neuropathic or nociplastic pain, pharmacologic options include the use of lidocaine patches and topical capsaicin