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It is contraindicated for use in pregnancy due to risk of teratogenicity

Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

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Since it is made by the cell, it would make sense to believe that rate of synthesis is regulated by cells

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The interaction between bacteria and bile