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Treatment of hypercholesterolemia rats with Co-Q10 alone or in combination with omega-3 (1,000 mg) regulated cholinergic functioning, reduced brain inflammation and oxidative stress, and increased the functional outcome verified through the histopathological evaluation of brain tissues (Ibrahim Fouad, 2020)

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Carnitine insufficiency, represented by increased AC/FC, in HF, especially in HFpEF, have also been previously reported by Yoshihisa et al