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For weight management, medications like semaglutide 2.4mg (Wegovy) and liraglutide 3mg (Saxenda) are subject to specific NICE criteria and are typically initiated by specialist weight management services (Tier 3 or 4), not in general practice

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Heterogeneity test was shown in S14-S22 Tables and funnel plots of publication bias were shown in S17 Fig

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