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Therapeutic Research Protocol Dose: 1.0 2.0 mg (= 2040 clicks) Duration: 3 6 weeks Frequency: Daily until target pigmentation observed Cycle Interval: 4 6 weeks off before repeating Goal / Description: Higher-dose schedule used in photoprotection and MC1R activation studies

Differential expression analysis consistently showed the most significant transcriptional alterations in IL7 low naive CD4 T cells (Supplementary Fig