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An orally available NNMT inhibitor if the animal bioavailability data translates to humans would have significant practical advantages

The affinity cell sorting procedure efficiently enriched positive cells from 20% to 98% in K-562 cells

attached proteolysis-targeting chimeras (PROTACs) to lactam cyclic peptide as ER-binding ligand, 6-aminocaproic acid as a linker, and a hydroxylated structure for recruiting E3 ligase known as 16 compound

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The statistical analyses were conducted using GraphPad Prism 9.0 (GraphPad Software, CA, USA), and the ShapiroWilk test was employed to check for normal data distribution

Benzi G, Moretti A