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This prolonged retention might increase intragastric pressure and potentially promote retrograde movement of gastric contents into the esophagus, particularly in patients with pre-existing lower esophageal sphincter dysfunction or hiatal hernia

In particular, this patient experienced worsening heart failure while discontinuing SGLT2 inhibitor

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The second study compared people on tirzepatide after they underwent a procedure to replace their hearts aortic valve

Snape, W

The review delves into the intricacies of different modification approaches, including N and C-terminal modifications, Fatty acid Side chain Modifications, and Large Molecule Conjugation Modifications, highlighting their rationale and resulting improvements in half-life, stability, receptor binding, and bioactivity