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Headache Dizziness Nausea / Vomiting Tingling sensation in the hands and feet Heart palpitations (NHS Choices, 2019) Other side effects and interactions with Vitamin B12: However, these are not the only potential side effects from B12 supplementation

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Taken together, the combined burden of on-target toxicity and off-target effects constrains the therapeutic window and constitutes a practical barrier to clinical development, making it essential to pair analog optimization with delivery strategies that confine exposure to lesions and minimize unintended pathway engagement in normal tissues