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The renal parameters of mice were evaluated by measuring hematocrit and renal clearance of 51Cr-EDTA at 20, 25, and 32 weeks after WBI with 240 kVp X-rays (1030 Gy in 2 fractions)

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Furthermore, as with the use of the combination of anti-CTLA-4 and anti-PD-1 or anti-PD-L1, the frequency and severity of irAEs were higher than with single immune checkpoint inhibitor monoclonal antibody treatment

The results of the global sensitivity analysis for the redox cycling parameters with respect to model OCR output are shown in Fig

Xentuzumab is also being investigated in a phase 2 trial as a combination with everolimus and exemestane in patients with HR+/HER2- advanced or metastatic breast cancer with recruitment ongoing and expected completion of the trial in 2022 (NCT03659136)

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