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Pesticides, herbicides in our food, and chemicals in beauty and cleaning products add to this toxic load

10.1016/j.biopha.2018.03.030 247 XiH.WangZ.LiM.DuanX.LiY

PERK phosphorylates the eukaryotic translation initiator factor 2 (eIF2), which increase the translation of transcription factor-4 (ATF4) and subsequently upregulating the expression of C/EBP homologous protein (CHOP) and tribbles homolog 3 (TRIB3)