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(4) Johansen PB, Nowak J, Skjaerbaek C, Flyvbjerg A, Andreassen TT, Wilken M, Orskov H

Consistently, our recent genome-wide CRISPR screens performed in the presence of mitochondrial inhibitors also identified that cell fitness defect in the SLC25A19 KOs can be buffered by a spectrum of mitochondrial inhibitors (Supplementary Fig

Second, private and public coverage is being restrained by worries about affordability

Theyre not a concern as long as everything else looks normal

Understanding that continued medication use will likely be necessary helps frame expectations appropriately

This suggests that the proportion of patients with long-term use of the medications is larger than indicated by analyses focusing on treatment discontinuation