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If you are on a GLP-1 medication and are experiencing changes in the appearance of your genitalia or physical discomfort due to skin laxity, this can be a result of sudden, significant weight loss

As of August 2025 it remains investigational

Can careful GLP-1 monitoring lower the risk of severe digestive symptoms

If your stomach is moving too slowly, these medications may not be absorbed as efficiently as they should be

The STEP 1 extension study showed that participants who discontinued semaglutide after 68 weeks regained approximately two-thirds of the lost weight within one year

However, certain patient populations might theoretically benefit from the anti-inflammatory properties of these agents when used for approved indications