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Furthermore, a major difference between the gastrointestinal system and other tissues is the gut microbiome

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Further supporting this, Lock and colleagues demonstrated that glutathione protects against 2-chloropropionic acid (CPA)-induced cerebellar toxicity by preserving thiol redox equilibrium and potentially interacting with NMDA receptor-mediated pathways

The Nrf2 pathway responds to ROS by activating the transcription of phase II detoxification enzymes