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Secondary outcomes included hospitalization for other substance use disorders, physical illnesses, and suicide attempts
The trial was stopped early after an interim analysis found that the relative risk of the primary outcome was significantly lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patientyears, respectively (hazard ratio = 0.70
The small-study effect was evaluated by the formal tests of Eggers and Beggs
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Cellular effects of pyocyanin, a secreted virulence factor of pseudomonas aeruginosa
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