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3.2 Systematic reviews and meta-analyses: three tiers of critical evidence Existing secondary research can be broadly categorized into three tiers: (i) PCOS-specific meta-analyses of RCTs (primarily focusing on weight, metabolism, and select endocrine markers)

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Given the evidence that a pulsatile pattern of GH secretion is important for many of its physiological actions, a strategy to augment physiological pulsatile GH secretion without inducing the side-effects of supraphysiological GH doses has been studied in HIV lipodystrophy with excess VAT and decreased endogenous GH secretion (144, 145)

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