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In clinical studies, therapeutic plasma exchange reduced 28-day mortality by 20.5% in severe sepsis patients, while other extracorporeal techniques, such as high-volume hemofiltration and hemoadsorption, showed significant reductions in inflammatory markers, though without consistent survival benefits [56]

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Rather, it fluctuates across the lifespan in response to factors like stress, sleep quality, exercise routine, medication, illness, hormones, relationship dynamics, and more