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doi:10.1016/j.ajpath.2012.08.004 Dragovic S, Boerma JS, van Bergen L, Vermeulen NP, Commandeur JN (2010) Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine

Gradual titration is essential to minimize gastrointestinal side effects

These reflect sterile compounding requirements, specialized delivery technology, or higher-cost active ingredients

In addition to fatigue, a deficiency of B12 can lead to other symptoms like pale skin, headaches, depression, gastrointestinal problems, difficulty concentrating, decreased mental function, mouth and tongue pain or inflammation, and paresthesia in your hands and feet

Anyone on medications that act on nitric oxide or vascular tone should review with a clinician

The American Diabetes Association recommends that people on Metformin have their B12 levels checked at least once a year