As featured in Microdose semaglutide delivers the same GLP-1 mechanism at a lower starting dose ideal for first-time patients who want to minimize side effects during ramp-up
Staying ahead of dehydration is particularly important, as many GLP-1 and GIP medications can reduce your thirst cue along with your hunger cue
Boosts Antioxidant Levels : High oxidative stress can impair GLP-1 secretion and function
The other medications in Hims previous weight loss program are still available, and they include: Bupropion: a commonly prescribed dopamine and norepinephrine reuptake inhibitor thats been shown to induce weight loss in some users.32 Metformin: Like GLP-1 medications, metformin is an anti-diabetic drug with weight loss benefits.33 Topiramate: This is typically a migraine drug, but its potential for weight loss has also been recently established.34 Naltrexone: Since its mainly used for those with substance use disorders to help curb drug cravings, it can be a tool for people with overeating problems who want to consume less.35 Given the efficacy and popularity of GLP-1 medications, it wouldnt surprise us if Hims program evolved to include them
Mechanistically, GLP-1s are thought to cross the blood-brain barrier and act directly on the brain, potentially reducing neuroinflammation, improving insulin signaling, and altering amyloid and tau pathology
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