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At the end of the experiment the mice were weighed and anesthetized, serum and liver samples were collected, weighed (liver) and preserved

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The impairment of the negative feedback was hypothesized to be due to the diminished sensitivity of the glucocorticoid receptors (the glucocorticoid resistance theory) secondary to reduced receptor function and expression, shown in large number of experimental, biological and molecular studies (258)

Long-term use and patient expectations GLP-1 therapy should be considered a long-term treatment

Presence of the enzyme and induction by oxidative conditions

Key Health Questions were devised and listed in Table 2