Serious but rare risks requiring immediate medical attention (call 999 or go to A&E if severe) include: Severe, persistent abdominal pain (potential pancreatitis) Signs of gallbladder problems (pain in upper right abdomen, fever, yellowing of skin or eyes) Chest pain, severe palpitations, or shortness of breath Severe mood changes or psychotic symptoms (more commonly associated with stimulants) Signs of severe dehydration or acute kidney injury Patients with pre-existing conditions require particular caution, including those with cardiovascular disease, history of pancreatitis, gallbladder disease, eating disorders, psychiatric conditions, or substance use history
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Journal of Cachexia, Sarcopenia and Muscle, 15(3), 455468
While gastrointestinal side effects are common with semaglutide, certain symptoms warrant prompt medical evaluation
Research consistently shows that 26% to 40% of the weight lost on GLP-1 receptor agonists comes from lean mass, which includes muscle
Combining adequate protein intake with resistance exercise further helps preserve muscle mass during weight loss
