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The benefit is dose-dependent and timing-sensitive: glutathione taken after acetaldehyde has already accumulated offers minimal relief because the oxidative cascade has already triggered inflammatory cytokine release

doi: 10.1194/jlr.M025403 74 HanXGuanZXuMZhangYYaoHMengFet al

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However, it was not possible at the time to isolate and identify the incretin and it was only when it became possible to measure insulin (through the work of Yalow and Berson in the late 50ties) that the incretin effect could be further substantiated