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This compound class has become the most active area in metabolic peptide research over the past decade, driven by the FDA approvals of semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) for diabetes and weight management indications

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HMEC1-hFcRn cells 63 were maintained in MCDB 131 medium (ThermoFisher) supplemented with 10% HI-FCS, 2 mM L-glutamine, 25 g/mL streptomycin, 25 U/mL penicillin, 10 ng/mL mouse epidermal growth factor (mEGFR) (Peprotech) and 1 g/mL hydrocortisone

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