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To test whether our model is able to distinguish between the two competing hypotheses, we adapted the model to represent the dissociation hypothesis (Supplement Section 2)

Additional critical pharmacological factors that dictate the bioavailability and efficacy of intranasal compounds include drug metabolism in the nasal cavity, degree of dissociation (pKa), chemical structure, drug half-life (t ), osmolarity and pH

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This approach helps patients maintain metabolic health while minimizing side effects such as nausea or GI upset

Statistical Analysis Results are shown as mean SD for continuous variables and number and percentage for categorical variables