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In vitro tumor cell-fibroblast co-culture systems demonstrated that the Notch signaling pathway activates CAFs, with IL-1 identified as an inflammatory trigger for NF-B pathway induction in CAFs [31]

doi: 10.1016/j.immuni.2016.06.011 69 LeeSYMoonSJKimEKSeoHBYangEJSonHJet al

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In 2021, to further clarify NPP, the IASP defined clearer diagnostic boundaries and criteria for NPP-related chronic pain, including: I