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Theres evidence that these drugs affect the gut-brain axis, he adds, which might influence motility in more complex ways, but the main culprit is delayed gastric emptying. The gut-brain axis is the information superhighway between your gut and your brain

Clin Chem 1992;38:493-5

However, their effects are variable and generally observed in only a minority of patients, making it challenging to predict treatment efficacy on an individual basis [9]

Non-invasive evaluation of pulmonary glutathione in the exhaled breath condensate of otherwise healthy alcoholics