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NADPH can suppress intracellular cystine-dependent disulfide stress by converting cystine into cysteine for GSH synthesis [14,48]
10.1016/j.tem.2011.12.008 12 FrosstP.BlomH.MilosR.GoyetteP.SheppardC.MatthewsR.et al
NADPH distinctly attenuated I/R induced phosphorylation and degradation of IB, expression of cyclooxygenase (Cox2), iNOS, and ROS production
The American Joint Replacement Registry 2022 Annual Report indicates the cumulative procedural volume for hip and knee arthroplasty grew by 14% in 2021, or 305,645 additional cases
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