The most commonly reported changes after stopping GLP-1 medications include: Return of appetite : The appetite-suppressing effects diminish, and many people notice increased hunger and food cravings returning to pre-treatment levels Weight regain : Clinical evidence consistently shows that most individuals regain weight after discontinuation, often within 312 months Rising blood glucose levels : For those with type 2 diabetes, HbA1c levels typically increase, sometimes returning to pre-treatment values Changes in eating patterns : Gastric emptying returns to normal speed, which may affect feelings of fullness after meals It's important to note that stopping GLP-1 medications is generally safe from a withdrawal perspectivethese drugs do not cause physical dependence or withdrawal symptoms in the way some medications do, and tapering is not typically required
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Data from clinical trials have been very promising on this front, but its reassuring to see that these medications are also useful in clinical settings that arent as highly controlled as clinical trials. White said future research should analyze predictors for weight loss in people with diabetes to better understand who would best respond to a GLP-1 agonist and examine changes in body weight for adults who are fully adherent to GLP-1 therapy
The included studies were relatively small but had good methodological quality
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