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With the recent FDA approval of an oral Wegovy pill marking an important shift in the GLP-1 landscape, Dr
Somatostatin, secreted from pancreatic -cells, acts as an inhibitory paracrine to suppress glucagon release from pancreatic -cells, and specific blockade of SSRT2 eliminates the inhibitory effect of GLP-1 on glucagon secretion
The reasons for this difference likely relate to the dual GLP-1/GIP mechanism of tirzepatide versus the pure GLP-1 action of semaglutide
The 4 boxes you must tick to get approved Commercial plans that will consider Wegovy require prior authorization
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