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Statements Author contributions WW and JL designed the review

Without co-stimulatory signals on the antigen-presenting cell (in this case the cancer cell), CD4+ T cells will not differentiate into effector cells in response to antigens, which prevents an effective immune response

However, clinical trials did show a significant increase in blood clots in diabetes patients taking Ozempic

doi: 10.1111/dom.14117 37 RomeraICebrin-CuencaAlvarez-GuisasolaFGomez-PeraltaF

Romero-Gmez M, Lawitz E, Shankar RR, Chaudhri E, Liu J, Lam RLH, Kaufman KD, Engel SS, Group (2023) A phase IIa active-comparator-controlled study to evaluate the efficacy and safety of efinopegdutide in patients with nonalcoholic fatty liver disease