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Biol Psychiatry 78:702710 Pearce R, Owen A, Daniel S, Jenner P, Marsden C (1997) Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease

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When GLP-1 binds to these receptors, it can shift macrophages from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype, inhibit the production of pro-inflammatory cytokines like TNF-, IL-1, and IL-6, increase anti-inflammatory adiponectin, and inhibit NF-B, a key regulator of pro-inflammatory gene expression

Shilajit is a sticky, black resin that is extracted from the Himalayan Mountains

Both compounds significantly suppressed the production of pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated mouse BV-2 microglial cells and in human peripheral blood mononuclear cell-derived macrophages ( Senkyunolides exhibit significant anti-inflammatory and anti-migraine effects

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