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[14] Tirzepatide, as a dual GIP/GLP-1 receptor agonist, may achieve higher weight reductions (15-22%) but is currently licensed only for diabetes in the UK

While there are no official carnitine intake recommendations, the estimated daily requirement for adults is between 20 and 200 mg (Kepka et al., 2020)

Overall, this work proposed a convenient, safe, and effective rectal drug delivery strategy, providing a new candidate for the prevention and treatment of radiation-induced proctitis, and also providing a reference for the design of multifunctional local delivery systems in radiation-associated tissue injury

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