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Pharmacological applications 4.1

Akt is deactivated and Bcl-2-associated death promoter (BAD) phosphorylation is lost in one pathway due to a stalled survival pathway, whereas Fas cell surface death receptor (FAS) is upregulated through stimulation of c-Jun-N-terminal kinase, which activates caspase-8, phosphorylates Fas-associated protein with death domain (FADD), and truncates BH3-interacting domain death agonist (BID)

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[9] Pharmacodynamic Interaction Assessment A pharmacodynamic (PD) interaction occurs when two agents affect the same physiological target or downstream pathway, producing additive, synergistic, or antagonistic effects even without altering each other's concentrations

It is not intended to treat or diagnose any condition, and is not for human consumption

Stapleton MJ, Hai FI (2023) Microplastics as an emerging contaminant of concern to our environment: a brief overview of the sources and implications