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Prediction of Broad Spectrum Resistance of Tumors Towards Anticancer Drugs

Abstract Improving radiation effect on tumor cells using radiosensitizers is gaining traction for improving chemoradiotherapy

Overall, the core molecular machinery of ferroptosis is regulated by various cellular signalling pathways and genes but is primarily mediated through two main pathways, namely, extrinsic or transporter-dependent pathways (e.g., reduced cysteine or glutamine uptake and increased iron uptake) and intrinsic or enzyme-regulated pathways (e.g., inhibition of glutathione (GSH) peroxidase 4 (GPX4) antioxidant system) (Fig

Nelson DB, Mitchell KG, Wang J, Fujimoto J, Godoy M, Behrens C, Zheng X, Zhang J, Sepesi B, Vaporciyan AA, Hofstetter WL, Mehran RJ, Rice DC, Walsh GL, Swisher SG , Moran CA, Kalhor N, Weissferdt A, Wistuba II, Roth JA, Antonoff MB