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Laboratory investigations in these patients often reveal low levels of hemoglobin, ferritin, total serum protein, phosphorus, calcium, and triglycerides, indicating significant nutritional compromise [12]

This is not necessarily a negative side effect but rather an indication of accelerated cell turnover, where underlying congestion is brought to the surface as the skin rapidly sheds old cells and regenerates new ones

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Gelotte CK, Zimmerman BA (2015): Pharmacokinetics, Safety, and Cardiovascular Tolerability of Phenylephrine HCl 10, 20, and 30 mg After a Single Oral Administration in Healthy Volunteers

Fibroblasts secrete various biological substances, such as Vascular Endothelial Growth Factor (VEGF)