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Conventional proteases like trypsin often provide insufficient cleavage due to limited recognition sites or steric hindrance from bulky modifications

Fibroblast activation protein (FAP) is a marker of activated fibroblast prominence

Sudo K, Xiao L, Wadhwa R, Shiozaki H, Elimova E, Taketa T, Blum MA, Lee JH, Bhutani MS, Weston B, Ross WA, Komaki R, Rice DC, Swisher SG, Hofstetter WL , Maru DM, Skinner HD, Ajani JA

More clinically relevant, however, are the downstream effects of rapid weight loss and altered metabolic signaling

While emerging evidence establishes ferroptosis as a pivotal mediator of SLE nephritis (LN) pathogenesislinking iron dyshomeostasis, immune cell dysfunction, and renal injuryand identifies GPX4 as a key regulatory checkpoint, several critical, insufficiently addressed research gaps persist