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Significant results typically emerge between weeks 8 and 16, after dose titration reaches the 5 to 10 mg range

[DOI] [PMC free article] [PubMed] [Google Scholar] Chen L, Kwong M, Lu R, Ginzinger D, Lee C, Leung L, Chan JY

Stabilized HIF-1 then translocates into the nucleus, where it forms a transcriptionally active heterodimer with HIF-1

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In contrast, no differences were observed in smoking abstinence rates (63% versus 65%, respectively) or cigarette cravings after 12 weeks in a different clinical trial that compared dulaglutide (1.5 mg weekly) plus varenicline to placebo plus varenicline in 255 daily smokers