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February 16, 2026
These compounds have demonstrated significant efficacy in improving glycemic control in patients with Type 2 diabetes (T2D) by enhancing insulin secretion and reducing glucagon release
However, the weight loss plateau can be a cause for concern
The ultimate pathways whereby these molecular changes may translate into changes in body weight and metabolic (dys)function are yet to be fully disclosed, but alterations in the hypothalamic proteome involved in inflammatory and apoptotic processes, as well as in autophagy and vesicular trafficking, may play a role
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