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showed that QUE increased the sensitivity of the PTX-resistant BC cell line MCF-7/PTX to PTX by inhibiting the EGFR/ERK axis (72)

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SGLT2 inhibitors may improve metabolic profiles in selected non-pregnant patients, but any such use must remain strictly outside pregnancy, under reliable contraception, and with guideline-consistent discontinuation before conception attempts because of urogenital adverse effects and contraindications during pregnancy (155, 156)

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