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A meta-analysis could not be conducted as the studies were too heterogeneous in numerous regards including therapy doses, regimens and route of administration, means of assessing pain, and variety of neuropathic conditions assessed

These NAD + -dependent deacetylases regulate mitochondrial biogenesis through transcriptional players such as the peroxisome proliferator-activated receptor gamma coactivator 1- (PGC-1), as well as pathways involved in DNA repair and redox balance [253, 254]

Indeed, it produced up to 8.7 1.0 mM butanoic acid and 7.5 1.6 mM isopentanoic acid when grown in aerobiosis with glutathione, ascorbic acid, and uric acid (Fig