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CagriSema is the only one with Phase 3 combo data and a pending FDA decision
Geoffrey Littlejohn, adjunct clinical professor at Monash University, said the concept needed clarification in a well-conducted double-blind placebo-controlled study
It temporarily relaxes targeted facial muscles to reduce the appearance of dynamic wrinkles, such as frown lines, forehead creases, and crow's feet
Botox addresses dynamic wrinkles--those caused by facial movement--while Thermage/XTherma treats static concerns like skin laxity and sagging
Subcutaneous tumor-derived LOX was shown to increase vascular endothelial growth factor (VEGF) expression and secretion, which then promotes angiogenesis by phosphorylation of protein kinase B, or Akt, through platelet-derived growth factor receptor (PDGFRB)